When do cross-bridges detach from actin?

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Multiple Choice

When do cross-bridges detach from actin?

Explanation:
Detachment of the cross-bridge occurs when ATP binds to the myosin head. This binding reduces myosin’s affinity for actin, causing the myosin head to release from the actin filament. After detachment, ATP is hydrolyzed to ADP and Pi to re-energize and re-cock the head for another cycle. Ca2+ rising is what allows cross-bridge formation by exposing the binding sites on actin through troponin-tropomyosin, while ADP release happens during the power stroke, not detachment.

Detachment of the cross-bridge occurs when ATP binds to the myosin head. This binding reduces myosin’s affinity for actin, causing the myosin head to release from the actin filament. After detachment, ATP is hydrolyzed to ADP and Pi to re-energize and re-cock the head for another cycle. Ca2+ rising is what allows cross-bridge formation by exposing the binding sites on actin through troponin-tropomyosin, while ADP release happens during the power stroke, not detachment.

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